1. The authors are in the Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. e-mail: Harvey_Cantor@dfci.harvard.edu

Abstract

A single molecule, osteopontin, seems to both amplify and quell the immune response in asthma—depending on the stage of the asthmatic reaction. The findings hint that, if given at the right stage, osteopontin might have value as a therapy (pages 570–578).

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