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Nature Medicine 13, 404-406 (1 April 2007) | doi:10.1038/nm0407-404;

Providing AID to p53 mutagenesis

Shigeo Takaishi & Timothy C Wang

The p53 tumor suppressor gene (also known as TP53) has been called the 'guardian of the genome' or the 'cellular gatekeeper'; it is the most commonly known mutated gene in human cancer cells. Mutations of this gene have been detected in about half of all cancers, including those arising from a wide spectrum of tissues.

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