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From the following article

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease

Jean-Pyo Lee, Mylvaganam Jeyakumar, Rodolfo Gonzalez, Hiroto Takahashi, Pei-Jen Lee, Rena C Baek, Dan Clark, Heather Rose, Gerald Fu, Jonathan Clarke, Scott McKercher, Jennifer Meerloo, Franz-Josef Muller, Kook In Park, Terry D Butters, Raymond A Dwek, Philip Schwartz, Gang Tong, David Wenger, Stuart A Lipton, Thomas N Seyfried, Frances M Platt & Evan Y Snyder

Nature Medicine 13, 439 - 447 (2007) Published online: 11 March 2007

doi:10.1038/nm1548

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Transplantation of mNSCs into the brains of Hexb-/- mice prolongs life, delays symptom onset and preserves motor function.

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Figure 2

mNSCs differentiate into a range of neural cell types in the Hexb-/- mouse cortex, including electrophysiologically active neurons.

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Figure 3

Transplanted mNSCs increase Hex levels and reduce GM2 and GA2 ganglioside storage.

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Figure 4

NSC transplantation interfaces with other therapeutic mechanisms.

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Figure 5

Both 'primary' (CNS-derived) and 'secondary' (hESC-derived) human NSC transplantation benefit Hexb-/- mice.

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Figure 6

hNSCs (derived from hESCs) stably engrafted in the Hexb-/- mouse cortex for at least 5.5 months after neonatal transplantation, differentiating into cells expressing neuronal and glial markers.

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