Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Premature poking: impulsivity, cocaine and dopamine

'Impulsivity' occurs frequently in people with addiction and other common disorders such as attention deficit hyperactivity disorder (ADHD). Experiments in rats suggest that reduced dopamine receptor availability in the brain's ventral striatum may underlie links between impulsivity and addiction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Impulsivity model.

Ann Thomson

References

  1. Dalley, J.W. et al. Science 315, 1267–1270 (2007).

    Article  CAS  Google Scholar 

  2. Regier, D.A. et al. J. Am. Med. Assoc. 264, 2511–2518 (1990).

    Article  CAS  Google Scholar 

  3. Uhl, G.R. NeuroRx 3, 295–301 (2006).

    Article  Google Scholar 

  4. Volkow, N.D. et al. Synapse 46, 79–82 (2002).

    Article  CAS  Google Scholar 

  5. Smith, S.S. et al. Arch. Gen. Psychiatry 49, 723–727 (1992).

    Article  CAS  Google Scholar 

  6. Xu, K. et al. Arch. Gen. Psychiatry 61, 597–606 (2004).

    Article  CAS  Google Scholar 

  7. Gelernter, J. et al. Hum. Mol. Genet. 15, 3498–3507 (2006).

    Article  CAS  Google Scholar 

  8. Winstanley, C.A., Eagle, D.M. & Robbins, T.W. Clin. Psychol. Rev. 26, 379–395 (2006).

    Article  Google Scholar 

  9. Robbins, T.W. Psychopharmacology (Berl.) 163, 362–380 (2002).

    Article  CAS  Google Scholar 

  10. Reynolds, B. Behav. Pharmacol. 17, 651–667 (2006).

    Article  Google Scholar 

  11. Hyman, S.E., Malenka, R.C. & Nestler, E.J. Annu. Rev. Neurosci. 29, 565–598 (2006).

    Article  CAS  Google Scholar 

  12. Clark, L., Robbins, T.W., Ersche, K.D. & Sahakian, B.J. Biol. Psychiatry 60, 515–522 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uhl, G. Premature poking: impulsivity, cocaine and dopamine. Nat Med 13, 413–414 (2007). https://doi.org/10.1038/nm0407-413

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0407-413

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing