News and Views
Nature Medicine 13, 411 - 413 (2007)
doi:10.1038/nm0407-411
T effectors outfox T regulators in autoimmunity
Thomas Prod'homme1, Martin S Weber1 & Scott S Zamvil1
- The authors are in the Department of Neurology and Program in Immunology, University of California San Francisco, San Francisco, California 94143, USA. e-mail: zamvil@ucsf.neuroimmunol.org
Abstract
Findings from a mouse model of multiple sclerosis suggest that regulatory T cells alone cannot outduel pathogenic T cells in the central nervous system. The observations may have implications for experimental approaches designed to dampen autoimmune diseases by infusion of regulatory T cells (pages 423–431).
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