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News and Views
Nature Medicine 13, 246 - 248 (2007)
doi:10.1038/nm0307-246
Long-distance affair with adrenal GRK2 hangs up heart failure
Stephen B Liggett1
- Stephen B. Liggett is in the Cardiopulmonary Genomics Program, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. e-mail: sligg001@umaryland.edu
Abstract
Modulation of events regulated by 
2-adrenergic receptors counteracts heart failure by restoring proper signaling from the adrenal gland to the heart (pages 315–323).
G protein–coupled receptors (GPCRs) are the largest superfamily of receptors in the human genome. These cell surface receptors transduce signals of an amazing diversity: vision, smell, central and peripheral neurotransmission, and a host of hormone, autocrine and paracrine actions regulating virtually every organ—including the heart, lung, kidney and endocrine organs.
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