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Nature Medicine 13, 242 - 244 (2007)
doi:10.1038/nm0307-242
Cracking the cytokine code in psoriasis
Brian J Nickoloff1
- Brian J. Nickoloff is in the Departments of Pathology, Microbiology and Immunology, Loyola University School of Medicine, Oncology Institute, Building 112, Room 301, 2160 South First Avenue, Maywood, Illinois 60153, USA. e-mail: bnickol@lumc.edu
Abstract
Psoriasis results from cross-talk between immune cells and keratinocytes in the skin. The nature of these signals now comes to light, revealing potential roles for IL-23 and a TH17 response.
Recent research has led to a shift in thinking about the pathology of Crohn disease, in which chronic inflammation damages the gastrointestinal track1. This paradigm shift highlights a key role for the interleukin (IL)-23 cytokine, rather than the previous emphasis on IL-12, as the driving force behind the persistent inflammatory reaction.
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