News and Views
Nature Medicine 13, 250 - 253 (2007)
doi:10.1038/nm0307-250
Regulatory T-cell development: is Foxp3 the decider?
Tyler J Curiel1
- Tyler J. Curiel is the director of the San Antonio Cancer Institute and scientific director of the Cancer Therapy & Research Center, San Antonio, Texas, USA. e-mail: curielt@uthscsa.edu
Abstract
Regulatory T cells (Tregs) have gone from obscurity to rock-star status in the past decade, prompting intense scrutiny—but what exactly are they? Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function.
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