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Nature Medicine 13, 241 - 242 (2007)
doi:10.1038/nm0307-241

The ABCs of bold beta-cell dysfunction in type 2 diabetes

Manu V Chakravarthy1 & Clay F Semenkovich1

  1. The authors are in the Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA. e-mail: mchakrav@wustl.edu e-mail: csemenko@wustl.edu


Cholesterol toxicity may damage pancreatic beta-cells, leading to decreased insulin secretion and impaired glucose tolerance (pages 340–347).

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