Safeguarding clinical trials - p107

doi:10.1038/nm0207-107

Abstract - Safeguarding clinical trials | Full Text - Safeguarding clinical trials | PDF (64 KB) - Safeguarding clinical trials

Reformed US malaria program garners critics' approval - p109

Charlotte Schubert

doi:10.1038/nm0207-109a

Abstract - Reformed US malaria program garners critics' approval | Full Text - Reformed US malaria program garners critics' approval | PDF (981 KB) - Reformed US malaria program garners critics' approval

Supplement makers face bitter pill - p109

Meredith Wadman

doi:10.1038/nm0207-109b

Abstract - Supplement makers face bitter pill | Full Text - Supplement makers face bitter pill | PDF (981 KB) - Supplement makers face bitter pill

Tied up in red tape, European trials shut down - p110

Brandon Keim

doi:10.1038/nm0207-110a

Abstract - Tied up in red tape, European trials shut down | Full Text - Tied up in red tape, European trials shut down | PDF (693 KB) - Tied up in red tape, European trials shut down

Ambitious scheme for developing world trials in 'big trouble' - p110

Brandon Keim

doi:10.1038/nm0207-110b

Abstract - Ambitious scheme for developing world trials in 'big trouble' | Full Text - Ambitious scheme for developing world trials in 'big trouble' | PDF (693 KB) - Ambitious scheme for developing world trials in 'big trouble'

Australia set to test insulin 'vaccine' for juvenile diabetes - p111

Simon Grose

doi:10.1038/nm0207-111a

Abstract - Australia set to test insulin 'vaccine' for juvenile diabetes | Full Text - Australia set to test insulin 'vaccine' for juvenile diabetes | PDF (290 KB) - Australia set to test insulin 'vaccine' for juvenile diabetes

US proposal to expand access to untested drugs draws fire - p111

Emily Waltz

doi:10.1038/nm0207-111b

Abstract - US proposal to expand access to untested drugs draws fire | Full Text - US proposal to expand access to untested drugs draws fire | PDF (290 KB) - US proposal to expand access to untested drugs draws fire

Biomass fuels blamed for premature deaths in rural settings - p112

T.V. Padma

doi:10.1038/nm0207-112a

Abstract - Biomass fuels blamed for premature deaths in rural settings | Full Text - Biomass fuels blamed for premature deaths in rural settings | PDF (757 KB) - Biomass fuels blamed for premature deaths in rural settings

British scientists find patent loophole - p112

Brandon Keim

doi:10.1038/nm0207-112b

Abstract - British scientists find patent loophole | Full Text - British scientists find patent loophole | PDF (757 KB) - British scientists find patent loophole

Vikram Kumar - p113

Brandon Keim

doi:10.1038/nm0207-113

Abstract - Vikram Kumar | Full Text - Vikram Kumar | PDF (550 KB) - Vikram Kumar

News in brief - pp114 - 115

doi:10.1038/nm0207-114

Full Text - News in brief | PDF (1,281 KB) - News in brief

Gut warfare - pp116 - 117

Erika Check

doi:10.1038/nm0207-116

Abstract - Gut warfare | Full Text - Gut warfare | PDF (814 KB) - Gut warfare

Large stem cell grafts could lead to erroneous interpretations of behavioral results? - p118

Nicolaj Strøyer Christophersen & Patrik Brundin

doi:10.1038/nm0207-118a

Full Text - Large stem cell grafts could lead to erroneous interpretations of behavioral results? | PDF (70 KB) - Large stem cell grafts could lead to erroneous interpretations of behavioral results?

Large stem cell grafts could lead to erroneous interpretations of behavioral results? - pp118 - 119

Steven A Goldman, Neeta S Roy, M Flint Beal & Carine Cleren

doi:10.1038/nm0207-118b

Full Text - Large stem cell grafts could lead to erroneous interpretations of behavioral results? | PDF (84 KB) - Large stem cell grafts could lead to erroneous interpretations of behavioral results?

Where is the problem in the Ramón y Cajal program? - pp119 - 120

Luis Sanz-Menéndez

doi:10.1038/nm0207-119

Full Text - Where is the problem in the Ramón y Cajal program? | PDF (75 KB) - Where is the problem in the Ramón y Cajal program?

The past, present and future of neural prosthetics - p123

doi:10.1038/nm0207-123

Full Text - The past, present and future of neural prosthetics | PDF (207 KB) - The past, present and future of neural prosthetics

ACE inhibitor bulks up muscle - pp125 - 126

Jeffrey S Chamberlain

doi:10.1038/nm0207-125

Abstract - ACE inhibitor bulks up muscle | Full Text - ACE inhibitor bulks up muscle | PDF (289 KB) - ACE inhibitor bulks up muscle

See also: Letter by Cohn et al.

Orexins: looking forward to sleep, back at addiction - pp126 - 128

Thomas E Scammell & Clifford B Saper

doi:10.1038/nm0207-126

Abstract - Orexins: looking forward to sleep, back at addiction | Full Text - Orexins: looking forward to sleep, back at addiction | PDF (464 KB) - Orexins: looking forward to sleep, back at addiction

See also: Article by Brisbare-Roch et al.

Receptor feasts on sugar and cholesterol - pp128 - 129

Joseph T Rodgers & Pere Puigserver

doi:10.1038/nm0207-128

Abstract - Receptor feasts on sugar and cholesterol | Full Text - Receptor feasts on sugar and cholesterol | PDF (168 KB) - Receptor feasts on sugar and cholesterol

Seeing what Alzheimer saw - pp129 - 131

Mony J de Leon, Lisa Mosconi & Jean Logan

doi:10.1038/nm0207-129

Abstract - Seeing what Alzheimer saw | Full Text - Seeing what Alzheimer saw | PDF (704 KB) - Seeing what Alzheimer saw

A prize catch for diabetic retinopathy - pp131 - 132

Thomas W Gardner & David A Antonetti

doi:10.1038/nm0207-131

Abstract - A prize catch for diabetic retinopathy | Full Text - A prize catch for diabetic retinopathy | PDF (129 KB) - A prize catch for diabetic retinopathy

See also: Article by Gao et al.

Eating bone or adding it: the Wnt pathway decides - pp133 - 134

Steven R Goldring & Mary B Goldring

doi:10.1038/nm0207-133

Abstract - Eating bone or adding it: the Wnt pathway decides | Full Text - Eating bone or adding it: the Wnt pathway decides | PDF (169 KB) - Eating bone or adding it: the Wnt pathway decides

See also: Article by Diarra et al.

Research highlights - pp136 - 137

doi:10.1038/nm0207-136

Full Text - Research highlights | PDF (804 KB) - Research highlights

A brief history of T_H17, the first major revision in the T_H1/T_H2 hypothesis of T cell–mediated tissue damage - pp139 - 145

Lawrence Steinman

doi:10.1038/nm1551

Abstract - A brief history of T: H: 17, the first major revision in the T: H: 1/T: H: 2 hypothesis of T cell-mediated tissue damage | Full Text - A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage | PDF (316 KB) - A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract - pp147 - 149

J M Nicholls, M C W Chan, W Y Chan, H K Wong, C Y Cheung, D L W Kwong, M P Wong, W H Chui, L L M Poon, S W Tsao, Y Guan & J S M Peiris

doi:10.1038/nm1529

Abstract - Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract | Full Text - Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract | PDF (348 KB) - Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract | Supplementary information

Promotion of sleep by targeting the orexin system in rats, dogs and humans - pp150 - 155

Catherine Brisbare-Roch, Jasper Dingemanse, Ralf Koberstein, Petra Hoever, Hamed Aissaoui, Susan Flores, Celia Mueller, Oliver Nayler, Joop van Gerven, Sanne L de Haas, Patrick Hess, Changbin Qiu, Stephan Buchmann, Michael Scherz, Thomas Weller, Walter Fischli, Martine Clozel & François Jenck

doi:10.1038/nm1544

Abstract - Promotion of sleep by targeting the orexin system in rats, dogs and humans | Full Text - Promotion of sleep by targeting the orexin system in rats, dogs and humans | PDF (207 KB) - Promotion of sleep by targeting the orexin system in rats, dogs and humans | Supplementary information

See also: News and Views by Scammell & Saper

Dickkopf-1 is a master regulator of joint remodeling - pp156 - 163

Danielle Diarra, Marina Stolina, Karin Polzer, Jochen Zwerina, Michael S Ominsky, Denise Dwyer, Adelheid Korb, Josef Smolen, Markus Hoffmann, Clemens Scheinecker, Desiree van der Heide, Robert Landewe, Dave Lacey, William G Richards & Georg Schett

doi:10.1038/nm1538

Abstract - Dickkopf-1 is a master regulator of joint remodeling | Full Text - Dickkopf-1 is a master regulator of joint remodeling | PDF (912 KB) - Dickkopf-1 is a master regulator of joint remodeling | Supplementary information

See also: News and Views by Goldring & Goldring

Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide - pp164 - 170

Philipp A Lang, Marcus Schenck, Jan P Nicolay, Jan Ulrich Becker, Daniela S Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A Klarl, Herbert Rübben, Kurt W Schmid, Klaus Mann, Sibylle Hildenbrand, Harald Hefter, Stephan M Huber, Thomas Wieder, Andreas Erhardt, Dieter Häussinger, Erich Gulbins & Florian Lang

doi:10.1038/nm1539

Abstract - Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide | Full Text - Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide | PDF (414 KB) - Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide | Supplementary information

Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins - pp171 - 180

Tony K T Lam, Roger Gutierrez-Juarez, Alessandro Pocai, Sanjay Bhanot, Patrick Tso, Gary J Schwartz & Luciano Rossetti

doi:10.1038/nm1540

Abstract - Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins | Full Text - Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins | PDF (333 KB) - Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins | Supplementary information

Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation - pp181 - 188

Ben-Bo Gao, Allen Clermont, Susan Rook, Stephanie J Fonda, Vivek J Srinivasan, Maciej Wojtkowski, James G Fujimoto, Robert L Avery, Paul G Arrigg, Sven-Erik Bursell, Lloyd Paul Aiello & Edward P Feener

doi:10.1038/nm1534

Abstract - Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation | Full Text - Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation | PDF (365 KB) - Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation | Supplementary information

See also: News and Views by Gardner & Antonetti

Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity - pp189 - 197

Jane A Leopold, Aamir Dam, Bradley A Maron, Anne W Scribner, Ronglih Liao, Diane E Handy, Robert C Stanton, Bertram Pitt & Joseph Loscalzo

doi:10.1038/nm1545

Abstract - Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity | Full Text - Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity | PDF (331 KB) - Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity | Supplementary information

Disruption of methylarginine metabolism impairs vascular homeostasis - pp198 - 203

James Leiper, Manasi Nandi, Belen Torondel, Judith Murray-Rust, Mohammed Malaki, Bernard O'Hara, Sharon Rossiter, Shelagh Anthony, Melanie Madhani, David Selwood, Caroline Smith, Beata Wojciak-Stothard, Alain Rudiger, Ray Stidwill, Neil Q McDonald & Patrick Vallance

doi:10.1038/nm1543

First paragraph - Disruption of methylarginine metabolism impairs vascular homeostasis | Full Text - Disruption of methylarginine metabolism impairs vascular homeostasis | PDF (287 KB) - Disruption of methylarginine metabolism impairs vascular homeostasis | Supplementary information

See also: News and Views by Gardner & Antonetti

Angiotensin II type 1 receptor blockade attenuates TGF-–induced failure of muscle regeneration in multiple myopathic states - pp204 - 210

Ronald D Cohn, Christel van Erp, Jennifer P Habashi, Arshia A Soleimani, Erin C Klein, Matthew T Lisi, Matthew Gamradt, Colette M ap Rhys, Tammy M Holm, Bart L Loeys, Francesco Ramirez, Daniel P Judge, Christopher W Ward & Harry C Dietz

doi:10.1038/nm1536

First paragraph - Angiotensin II type 1 receptor blockade attenuates TGF-[beta]-induced failure of muscle regeneration in multiple myopathic states | Full Text - Angiotensin II type 1 receptor blockade attenuates TGF-–induced failure of muscle regeneration in multiple myopathic states | PDF (729 KB) - Angiotensin II type 1 receptor blockade attenuates TGF-–induced failure of muscle regeneration in multiple myopathic states | Supplementary information

See also: News and Views by Chamberlain

Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein - pp211 - 217

Kevin C O'Connor, Katherine A McLaughlin, Philip L De Jager, Tanuja Chitnis, Estelle Bettelli, Chenqi Xu, William H Robinson, Sunil V Cherry, Amit Bar-Or, Brenda Banwell, Hikoaki Fukaura, Toshiyuki Fukazawa, Silvia Tenembaum, Susan J Wong, Norma P Tavakoli, Zhannat Idrissova, Vissia Viglietta, Kevin Rostasy, Daniela Pohl, Russell C Dale, Mark Freedman, Lawrence Steinman, Guy J Buckle, Vijay K Kuchroo, David A Hafler & Kai W Wucherpfennig

doi:10.1038/nm1488

Abstract - Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein | Full Text - Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein | PDF (314 KB) - Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein | Supplementary information

Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection - pp218 - 223

Y M Dennis Lo, Nancy B Y Tsui, Rossa W K Chiu, Tze K Lau, Tse N Leung, Macy M S Heung, Ageliki Gerovassili, Yongjie Jin, Kypros H Nicolaides, Charles R Cantor & Chunming Ding

doi:10.1038/nm1530

Abstract - Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection | Full Text - Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection | PDF (296 KB) - Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection | Supplementary information

Corrigendum: In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' - p224

Carlo Gambacorti-Passerini, Lucia Tornaghi, Anna Franceschino, Rocco Piazza, Gianmarco Corneo & Enrico Pogliani

doi:10.1038/nm0207-224

Full Text - Corrigendum: In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' | PDF (43 KB) - Corrigendum: In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'