1. The authors are at the Dana-Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, Massachusetts 02115, USA. e-mail: pere_puigserver@dfci.harvard.edu

Abstract

The nuclear hormone receptor LXR—best known for sensing cholesterol metabolites—also responds to glucose. The findings give LXR a central role in modulating the body's response to metabolic inputs.

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