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Nature Medicine 13, 1417–1418 (1 December 2007) | doi:10.1038/nm1207-1417

Incapacitating the immune system in cystic fibrosis

Ian Sabroe & Moira K B Whyte

In cystic fibrosis, the immune system bombards bacteria invading the airways, but the effort does not clear the pathogen. Now, Hartl et al. show how the inflammatory response is disarmed in a series of events that favor persistent infection.