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Nature Medicine 13, 1415–1417 (1 December 2007) | doi:10.1038/nm1207-1415
Putting the heat on cancer
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Abstract
The heat shock response is an ancient and evolutionarily conserved mechanism orchestrated by the transcription factor heat shock factor-1 (HSF1). The main job of HSF1 is to regulate the induction of molecular chaperones and other heat shock proteins—permitting cell survival under stressful, protein-damaging conditions.
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