Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 13, 1415 - 1417 (2007)
doi:10.1038/nm1207-1415
Putting the heat on cancer
Paul Workman1 & Emmanuel de Billy1
- Paul Workman and Emmanuel de Billy are in the Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK e-mail: paul.workman@icr.ac.uk
Abstract
Two studies highlight the role of the heat shock response in initiating and maintaining cancer.
The heat shock response is an ancient and evolutionarily conserved mechanism orchestrated by the transcription factor heat shock factor-1 (HSF1). The main job of HSF1 is to regulate the induction of molecular chaperones and other heat shock proteins—permitting cell survival under stressful, protein-damaging conditions.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors functionThe EMBO Journal Article (04 Apr 2007)
BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responsesThe EMBO Journal Article (11 Jul 2007)
