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Technical Report
Nature Medicine 13, 1382-1387 (1 November 2007) | doi:10.1038/nm1650;
Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy
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Abstract
Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-13C]pyruvate that the lactate dehydrogenase–catalyzed flux of 13C label between the carboxyl groups of pyruvate and lactate in the tumor can be measured using 13C magnetic resonance spectroscopy and spectroscopic imaging, and that this flux is inhibited within 24 h of chemotherapy.
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