Table of contents


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Editorial

The long and short of it p1265

doi:10.1038/nm1107-1265


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News

Researchers look for 'sweet' method to diagnose cancer p1267

Cassandra Willyard

doi:10.1038/nm1107-1267


Program targets undergrads to make an early start on science p1268

Emma Marris

doi:10.1038/nm1107-1268


New law gives FDA more influence to monitor drug safety p1269

Meredith Wadman

doi:10.1038/nm1107-1269


News in brief pp1270 - 1271

doi:10.1038/nm1107-1270


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News Feature

Blue's clues pp1272 - 1273

Cassandra Willyard

doi:10.1038/nm1107-1272


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Q&A

Straight talk from... Victoria Hale p1274

Erika Check Hayden

doi:10.1038/nm1107-1274


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Correspondence

Reply to 'Must maternity medicine be reborn?' p1275

Jennifer Block

doi:10.1038/nm1107-1275a


Reply to 'pH paper trumps expensive kits in measuring acidity' p1275

Biji T Kurien

doi:10.1038/nm1107-1275b


Reply to 'Poor trial design leaves gene therapy death a mystery' p1276

H Stewart Parker

doi:10.1038/nm1107-1276a


Microarrays: retracing steps pp1276 - 1277

Kevin R Coombes, Jing Wang & Keith A Baggerly

doi:10.1038/nm1107-1276b


Reply to 'Microarrays: retracing steps' pp1277 - 1278

Anil Potti & Joseph R Nevins

doi:10.1038/nm1107-1277


Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many' p1278

Raymond P Warrell, Jr

doi:10.1038/nm1107-1278


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Book Review

The history and ideology of allergies p1279

Fernando Martinez reviews Breathing Space: How Allergies Shape Our Lives and Landscapes by Gregg Mitman

doi:10.1038/nm1107-1279


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News and Views

A deer in the headlights: BAMBI meets liver fibrosis pp1281 - 1282

Scott L Friedman

doi:10.1038/nm1107-1281

See also: Article by Seki et al.


Blocking HDACs boosts regulatory T cells pp1282 - 1284

Pavan Reddy & Weiping Zou

doi:10.1038/nm1107-1282

See also: Article by Tao et al.


Preventing kidney cell suicide pp1284 - 1285

Michael Brownlee

doi:10.1038/nm1107-1284

See also: Article by Isermann et al.


APC and colon cancer: two hits for one pp1286 - 1287

Craig J Ceol, David Pellman & Leonard I Zon

doi:10.1038/nm1107-1286


Seeking the source of schizophrenia p1287

Charlotte Schubert

doi:10.1038/nm1107-1287


Worms tame mast cells pp1288 - 1289

Edward J Pearce

doi:10.1038/nm1107-1288

See also: Letter by Melendez et al.


A MSC-ing link in metastasis? pp1289 - 1291

Douglas R Hurst & Danny R Welch

doi:10.1038/nm1107-1289


Platelets budding off the mothership p1291

Charlotte Schubert

doi:10.1038/nm1107-1291


Research Highlights p1293

doi:10.1038/nm1107-1293


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Brief Communication

B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates pp1295 - 1298

Chengyang Liu, Hooman Noorchashm, Jennifer A Sutter, Mina Naji, Eline Luning Prak, Jean Boyer, Taryn Green, Michael R Rickels, John E Tomaszewski, Brigitte Koeberlein, Zhonglin Wang, Michelle E Paessler, Ergun Velidedeoglu, Susan Y Rostami, Ming Yu, Clyde F Barker & Ali Naji

doi:10.1038/nm1673


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Articles

Deacetylase inhibition promotes the generation and function of regulatory T cells pp1299 - 1307

Ran Tao, Edwin F de Zoeten, Engin Özkaynak, Chunxia Chen, Liqing Wang, Paige M Porrett, Bin Li, Laurence A Turka, Eric N Olson, Mark I Greene, Andrew D Wells & Wayne W Hancock

doi:10.1038/nm1652

See also: News and Views by Reddy & Zou


Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease pp1308 - 1315

Markus Weckmann, Adam Collison, Jodie L Simpson, Matthias V Kopp, Peter A B Wark, Mark J Smyth, Hideo Yagita, Klaus I Matthaei, Nicole Hansbro, Bruce Whitehead, Peter G Gibson, Paul S Foster & Joerg Mattes

doi:10.1038/nm1660


Extralymphatic virus sanctuaries as a consequence of potent T-cell activation pp1316 - 1323

Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Philipp A Lang, Katja Fink, Stefan Freigang, Panco Georgiev, Lars Hangartner, Raphael Zellweger, Andreas Bergthaler, Ahmed N Hegazy, Bruno Eschli, Alexandre Theocharides, Lukas T Jeker, Doron Merkler, Bernhard Odermatt, Martin Hersberger, Hans Hengartner & Rolf M Zinkernagel

doi:10.1038/nm1670


TLR4 enhances TGF-beta signaling and hepatic fibrosis pp1324 - 1332

Ekihiro Seki, Samuele De Minicis, Christoph H Österreicher, Johannes Kluwe, Yosuke Osawa, David A Brenner & Robert F Schwabe

doi:10.1038/nm1663

See also: News and Views by Friedman


Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1 pp1333 - 1340

Heiko Johnen, Shu Lin, Tamara Kuffner, David A Brown, Vicky Wang-Wei Tsai, Asne R Bauskin, Liyun Wu, Greg Pankhurst, Lele Jiang, Simon Junankar, Mark Hunter, W Douglas Fairlie, Nicola J Lee, Ronaldo F Enriquez, Paul A Baldock, Eva Corey, Fred S Apple, MaryAnn M Murakami, En-Ju Lin, Chuansong Wang, Matthew J During, Amanda Sainsbury, Herbert Herzog & Samuel N Breit

doi:10.1038/nm1677


STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression pp1341 - 1348

Qian Zhang, Hong Y Wang, Xiaobin Liu & Mariusz A Wasik

doi:10.1038/nm1659


Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis pp1349 - 1358

Berend Isermann, Ilya A Vinnikov, Thati Madhusudhan, Stefanie Herzog, Muhammed Kashif, Janusch Blautzik, Marcus A F Corat, Martin Zeier, Erwin Blessing, Jun Oh, Bruce Gerlitz, David T Berg, Brian W Grinnell, Triantafyllos Chavakis, Charles T Esmon, Hartmut Weiler, Angelika Bierhaus & Peter P Nawroth

doi:10.1038/nm1667

See also: News and Views by Brownlee


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Letters

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins pp1359 - 1362

Sandip Ray, Markus Britschgi, Charles Herbert, Yoshiko Takeda-Uchimura, Adam Boxer, Kaj Blennow, Leah F Friedman, Douglas R Galasko, Marek Jutel, Anna Karydas, Jeffrey A Kaye, Jerzy Leszek, Bruce L Miller, Lennart Minthon, Joseph F Quinn, Gil D Rabinovici, William H Robinson, Marwan N Sabbagh, Yuen T So, D Larry Sparks, Massimo Tabaton, Jared Tinklenberg, Jerome A Yesavage, Robert Tibshirani & Tony Wyss-Coray

doi:10.1038/nm1653


Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human pp1363 - 1367

Shuichi Hiraoka, Tatsuya Furuichi, Gen Nishimura, Shunichi Shibata, Masaki Yanagishita, David L Rimoin, Andrea Superti-Furga, Peter G Nikkels, Minako Ogawa, Kayoko Katsuyama, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Nobuhiro Ishida, Kyoichi Isono, Yutaka Sanai, Daniel H Cohn, Haruhiko Koseki & Shiro Ikegawa

doi:10.1038/nm1655


CD16 promotes Escherichia coli sepsis through an FcRbold gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation pp1368 - 1374

Fabiano Pinheiro da Silva, Meryem Aloulou, David Skurnik, Marc Benhamou, Antoine Andremont, Irineu T Velasco, Murilo Chiamolera, J Sjef Verbeek, Pierre Launay & Renato C Monteiro

doi:10.1038/nm1665


Inhibition of FcepsilonRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes pp1375 - 1381

Alirio J Melendez, Margaret M Harnett, Peter N Pushparaj, WS Fred Wong, Hwee Kee Tay, Charles P McSharry & William Harnett

doi:10.1038/nm1654

See also: News and Views by Pearce


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Technical Report

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy pp1382 - 1387

Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu, Mathilde Lerche, Jan Wolber, Klaes Golman, Jan Henrik Ardenkjaer-Larsen & Kevin M Brindle

doi:10.1038/nm1650


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Corrigendum

Corrigenda: Genomic signatures to guide the use of chemotherapeutics p1388

Anil Potti, Holly K Dressman, Andrea Bild, Richard F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S Ginsburg, Phillip Febbo, Johnathan Lancaster & Joseph R Nevins

doi:10.1038/nm1107-1388


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