The long and short of it - p1265

doi:10.1038/nm1107-1265

Abstract - | Full Text - The long and short of it | PDF (85 KB) - The long and short of it

Researchers look for 'sweet' method to diagnose cancer - p1267

Cassandra Willyard

doi:10.1038/nm1107-1267

Full Text - Researchers look for 'sweet' method to diagnose cancer | PDF (264 KB) - Researchers look for 'sweet' method to diagnose cancer

Program targets undergrads to make an early start on science - p1268

Emma Marris

doi:10.1038/nm1107-1268

Full Text - Program targets undergrads to make an early start on science | PDF (207 KB) - Program targets undergrads to make an early start on science

New law gives FDA more influence to monitor drug safety - p1269

Meredith Wadman

doi:10.1038/nm1107-1269

Full Text - New law gives FDA more influence to monitor drug safety | PDF (193 KB) - New law gives FDA more influence to monitor drug safety

News in brief - pp1270 - 1271

doi:10.1038/nm1107-1270

Abstract - | Full Text - News in brief | PDF (571 KB) - News in brief

Blue's clues - pp1272 - 1273

Cassandra Willyard

doi:10.1038/nm1107-1272

Abstract - | Full Text - Blue's clues | PDF (349 KB) - Blue's clues

Straight talk from... Victoria Hale - p1274

Erika Check Hayden

doi:10.1038/nm1107-1274

Abstract - | Full Text - Straight talk from... Victoria Hale | PDF (129 KB) - Straight talk from... Victoria Hale

Reply to 'Must maternity medicine be reborn?' - p1275

Jennifer Block

doi:10.1038/nm1107-1275a

Full Text - Reply to 'Must maternity medicine be reborn?' | PDF (80 KB) - Reply to 'Must maternity medicine be reborn?'

Reply to 'pH paper trumps expensive kits in measuring acidity' - p1275

Biji T Kurien

doi:10.1038/nm1107-1275b

Full Text - Reply to 'pH paper trumps expensive kits in measuring acidity' | PDF (80 KB) - Reply to 'pH paper trumps expensive kits in measuring acidity'

Reply to 'Poor trial design leaves gene therapy death a mystery' - p1276

H Stewart Parker

doi:10.1038/nm1107-1276a

Full Text - Reply to 'Poor trial design leaves gene therapy death a mystery' | PDF (82 KB) - Reply to 'Poor trial design leaves gene therapy death a mystery'

Microarrays: retracing steps - pp1276 - 1277

Kevin R Coombes, Jing Wang & Keith A Baggerly

doi:10.1038/nm1107-1276b

Full Text - Microarrays: retracing steps | PDF (160 KB) - Microarrays: retracing steps | Supplementary information

Reply to 'Microarrays: retracing steps' - pp1277 - 1278

Anil Potti & Joseph R Nevins

doi:10.1038/nm1107-1277

Full Text - Reply to 'Microarrays: retracing steps' | PDF (157 KB) - Reply to 'Microarrays: retracing steps' | Supplementary information

Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many' - p1278

Raymond P Warrell, Jr

doi:10.1038/nm1107-1278

Full Text - Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many' | PDF (81 KB) - Reply to 'Arsenic patent keeps drug for rare cancer out of reach for many'

The history and ideology of allergies - p1279

Fernando Martinez reviews Breathing Space: How Allergies Shape Our Lives and Landscapes by Gregg Mitman

doi:10.1038/nm1107-1279

Full Text - The history and ideology of allergies | PDF (130 KB) - The history and ideology of allergies

A deer in the headlights: BAMBI meets liver fibrosis - pp1281 - 1282

Scott L Friedman

doi:10.1038/nm1107-1281

Abstract - | Full Text - A deer in the headlights: BAMBI meets liver fibrosis | PDF (1,676 KB) - A deer in the headlights: BAMBI meets liver fibrosis

See also: Article by Seki et al.

Blocking HDACs boosts regulatory T cells - pp1282 - 1284

Pavan Reddy & Weiping Zou

doi:10.1038/nm1107-1282

Abstract - | Full Text - Blocking HDACs boosts regulatory T cells | PDF (295 KB) - Blocking HDACs boosts regulatory T cells

See also: Article by Tao et al.

Preventing kidney cell suicide - pp1284 - 1285

Michael Brownlee

doi:10.1038/nm1107-1284

Abstract - | Full Text - Preventing kidney cell suicide | PDF (242 KB) - Preventing kidney cell suicide

See also: Article by Isermann et al.

APC and colon cancer: two hits for one - pp1286 - 1287

Craig J Ceol, David Pellman & Leonard I Zon

doi:10.1038/nm1107-1286

Abstract - | Full Text - APC and colon cancer: two hits for one | PDF (481 KB) - APC and colon cancer: two hits for one

Seeking the source of schizophrenia - p1287

Charlotte Schubert

doi:10.1038/nm1107-1287

Full Text - Seeking the source of schizophrenia | PDF (173 KB) - Seeking the source of schizophrenia

Worms tame mast cells - pp1288 - 1289

Edward J Pearce

doi:10.1038/nm1107-1288

Abstract - | Full Text - Worms tame mast cells | PDF (547 KB) - Worms tame mast cells

See also: Letter by Melendez et al.

A MSC-ing link in metastasis? - pp1289 - 1291

Douglas R Hurst & Danny R Welch

doi:10.1038/nm1107-1289

Abstract - | Full Text - A MSC-ing link in metastasis? | PDF (638 KB) - A MSC-ing link in metastasis?

Platelets budding off the mothership - p1291

Charlotte Schubert

doi:10.1038/nm1107-1291

Full Text - Platelets budding off the mothership | PDF (142 KB) - Platelets budding off the mothership

Research Highlights - p1293

doi:10.1038/nm1107-1293

Full Text - Research Highlights | PDF (128 KB) - Research Highlights

B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates - pp1295 - 1298

Chengyang Liu, Hooman Noorchashm, Jennifer A Sutter, Mina Naji, Eline Luning Prak, Jean Boyer, Taryn Green, Michael R Rickels, John E Tomaszewski, Brigitte Koeberlein, Zhonglin Wang, Michelle E Paessler, Ergun Velidedeoglu, Susan Y Rostami, Ming Yu, Clyde F Barker & Ali Naji

doi:10.1038/nm1673

Abstract - | Full Text - B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates | PDF (393 KB) - B lymphocyte–directed immunotherapy promotes long-term islet allograft survival in nonhuman primates | Supplementary information

Deacetylase inhibition promotes the generation and function of regulatory T cells - pp1299 - 1307

Ran Tao, Edwin F de Zoeten, Engin Özkaynak, Chunxia Chen, Liqing Wang, Paige M Porrett, Bin Li, Laurence A Turka, Eric N Olson, Mark I Greene, Andrew D Wells & Wayne W Hancock

doi:10.1038/nm1652

Abstract - | Full Text - Deacetylase inhibition promotes the generation and function of regulatory T cells | PDF (570 KB) - Deacetylase inhibition promotes the generation and function of regulatory T cells | Supplementary information

See also: News and Views by Reddy & Zou

Critical link between TRAIL and CCL20 for the activation of T_H2 cells and the expression of allergic airway disease - pp1308 - 1315

Markus Weckmann, Adam Collison, Jodie L Simpson, Matthias V Kopp, Peter A B Wark, Mark J Smyth, Hideo Yagita, Klaus I Matthaei, Nicole Hansbro, Bruce Whitehead, Peter G Gibson, Paul S Foster & Joerg Mattes

doi:10.1038/nm1660

Abstract - | Full Text - Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease | PDF (426 KB) - Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease | Supplementary information

Extralymphatic virus sanctuaries as a consequence of potent T-cell activation - pp1316 - 1323

Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Philipp A Lang, Katja Fink, Stefan Freigang, Panco Georgiev, Lars Hangartner, Raphael Zellweger, Andreas Bergthaler, Ahmed N Hegazy, Bruno Eschli, Alexandre Theocharides, Lukas T Jeker, Doron Merkler, Bernhard Odermatt, Martin Hersberger, Hans Hengartner & Rolf M Zinkernagel

doi:10.1038/nm1670

Abstract - | Full Text - Extralymphatic virus sanctuaries as a consequence of potent T-cell activation | PDF (525 KB) - Extralymphatic virus sanctuaries as a consequence of potent T-cell activation | Supplementary information

TLR4 enhances TGF- signaling and hepatic fibrosis - pp1324 - 1332

Ekihiro Seki, Samuele De Minicis, Christoph H Österreicher, Johannes Kluwe, Yosuke Osawa, David A Brenner & Robert F Schwabe

doi:10.1038/nm1663

Abstract - | Full Text - TLR4 enhances TGF- signaling and hepatic fibrosis | PDF (543 KB) - TLR4 enhances TGF- signaling and hepatic fibrosis | Supplementary information

See also: News and Views by Friedman

Tumor-induced anorexia and weight loss are mediated by the TGF- superfamily cytokine MIC-1 - pp1333 - 1340

Heiko Johnen, Shu Lin, Tamara Kuffner, David A Brown, Vicky Wang-Wei Tsai, Asne R Bauskin, Liyun Wu, Greg Pankhurst, Lele Jiang, Simon Junankar, Mark Hunter, W Douglas Fairlie, Nicola J Lee, Ronaldo F Enriquez, Paul A Baldock, Eva Corey, Fred S Apple, MaryAnn M Murakami, En-Ju Lin, Chuansong Wang, Matthew J During, Amanda Sainsbury, Herbert Herzog & Samuel N Breit

doi:10.1038/nm1677

Abstract - | Full Text - Tumor-induced anorexia and weight loss are mediated by the TGF- superfamily cytokine MIC-1 | PDF (850 KB) - Tumor-induced anorexia and weight loss are mediated by the TGF- superfamily cytokine MIC-1 | Supplementary information

STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression - pp1341 - 1348

Qian Zhang, Hong Y Wang, Xiaobin Liu & Mariusz A Wasik

doi:10.1038/nm1659

Abstract - | Full Text - STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression | PDF (1,064 KB) - STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression | Supplementary information

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis - pp1349 - 1358

Berend Isermann, Ilya A Vinnikov, Thati Madhusudhan, Stefanie Herzog, Muhammed Kashif, Janusch Blautzik, Marcus A F Corat, Martin Zeier, Erwin Blessing, Jun Oh, Bruce Gerlitz, David T Berg, Brian W Grinnell, Triantafyllos Chavakis, Charles T Esmon, Hartmut Weiler, Angelika Bierhaus & Peter P Nawroth

doi:10.1038/nm1667

Abstract - | Full Text - Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis | PDF (641 KB) - Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis | Supplementary information

See also: News and Views by Brownlee

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins - pp1359 - 1362

Sandip Ray, Markus Britschgi, Charles Herbert, Yoshiko Takeda-Uchimura, Adam Boxer, Kaj Blennow, Leah F Friedman, Douglas R Galasko, Marek Jutel, Anna Karydas, Jeffrey A Kaye, Jerzy Leszek, Bruce L Miller, Lennart Minthon, Joseph F Quinn, Gil D Rabinovici, William H Robinson, Marwan N Sabbagh, Yuen T So, D Larry Sparks, Massimo Tabaton, Jared Tinklenberg, Jerome A Yesavage, Robert Tibshirani & Tony Wyss-Coray

doi:10.1038/nm1653

First paragraph - | Full Text - Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins | PDF (252 KB) - Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins | Supplementary information

Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human - pp1363 - 1367

Shuichi Hiraoka, Tatsuya Furuichi, Gen Nishimura, Shunichi Shibata, Masaki Yanagishita, David L Rimoin, Andrea Superti-Furga, Peter G Nikkels, Minako Ogawa, Kayoko Katsuyama, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Nobuhiro Ishida, Kyoichi Isono, Yutaka Sanai, Daniel H Cohn, Haruhiko Koseki & Shiro Ikegawa

doi:10.1038/nm1655

First paragraph - | Full Text - Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human | PDF (515 KB) - Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human | Supplementary information

CD16 promotes Escherichia coli sepsis through an FcR inhibitory pathway that prevents phagocytosis and facilitates inflammation - pp1368 - 1374

Fabiano Pinheiro da Silva, Meryem Aloulou, David Skurnik, Marc Benhamou, Antoine Andremont, Irineu T Velasco, Murilo Chiamolera, J Sjef Verbeek, Pierre Launay & Renato C Monteiro

doi:10.1038/nm1665

First paragraph - | Full Text - CD16 promotes Escherichia coli sepsis through an FcR inhibitory pathway that prevents phagocytosis and facilitates inflammation | PDF (424 KB) - CD16 promotes Escherichia coli sepsis through an FcR inhibitory pathway that prevents phagocytosis and facilitates inflammation | Supplementary information

Inhibition of FcRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes - pp1375 - 1381

Alirio J Melendez, Margaret M Harnett, Peter N Pushparaj, WS Fred Wong, Hwee Kee Tay, Charles P McSharry & William Harnett

doi:10.1038/nm1654

First paragraph - | Full Text - Inhibition of FcRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes | PDF (320 KB) - Inhibition of FcRI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes | Supplementary information

See also: News and Views by Pearce

Detecting tumor response to treatment using hyperpolarized ¹³C magnetic resonance imaging and spectroscopy - pp1382 - 1387

Sam E Day, Mikko I Kettunen, Ferdia A Gallagher, De-En Hu, Mathilde Lerche, Jan Wolber, Klaes Golman, Jan Henrik Ardenkjaer-Larsen & Kevin M Brindle

doi:10.1038/nm1650

First paragraph - | Full Text - Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy | PDF (544 KB) - Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy | Supplementary information

Corrigenda: Genomic signatures to guide the use of chemotherapeutics - p1388

Anil Potti, Holly K Dressman, Andrea Bild, Richard F Riedel, Gina Chan, Robyn Sayer, Janiel Cragun, Hope Cottrill, Michael J Kelley, Rebecca Petersen, David Harpole, Jeffrey Marks, Andrew Berchuck, Geoffrey S Ginsburg, Phillip Febbo, Johnathan Lancaster & Joseph R Nevins

doi:10.1038/nm1107-1388

Full Text - Corrigenda: Genomic signatures to guide the use of chemotherapeutics | PDF (43 KB) - Corrigenda: Genomic signatures to guide the use of chemotherapeutics