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Letter
Nature Medicine 13, 1359 - 1362 (2007)
Published online: 14 October 2007 | doi:10.1038/nm1653
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Sandip Ray1,16, Markus Britschgi2,16, Charles Herbert1, Yoshiko Takeda-Uchimura2, Adam Boxer3, Kaj Blennow4, Leah F Friedman5, Douglas R Galasko6, Marek Jutel7, Anna Karydas3, Jeffrey A Kaye8, Jerzy Leszek9, Bruce L Miller3, Lennart Minthon10, Joseph F Quinn8, Gil D Rabinovici3, William H Robinson11, Marwan N Sabbagh12, Yuen T So2, D Larry Sparks12, Massimo Tabaton13, Jared Tinklenberg5, Jerome A Yesavage5, Robert Tibshirani14 & Tony Wyss-Coray2,15
Abstract
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's and control subjects with close to 90% accuracy and to identify patients who had mild cognitive impairment that progressed to Alzheimer's disease 2–6 years later. Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
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