Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A MSC-ing link in metastasis?

Nature Medicine volume 13, pages 1289–1291 (2007)Cite this article

Mesenchymal stem cells promote the dissemination of neoplastic cells in a mouse model of breast cancer. The findings sound a cautionary note for anticancer therapies that rely on these cells and provoke a re-evaluation of how metastases form.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Bone marrow–derived stem cells have multiple roles in assisting or regulating cancer metastasis.

Kim Caesar

References

  1. Fidler, I.J. Nat. New Biol. 242, 148–149 (1973).

    Article  CAS  Google Scholar 

  2. Thiery, J.P. & Sleeman, J.P. Nat. Rev. Mol. Cell Biol. 7, 131–142 (2006).

    Article  CAS  Google Scholar 

  3. Ling, V., Chambers, A.F., Harris, J.F. & Hill, R.P. J. Cell. Physiol. Suppl. 3, 99–103 (1984).

    Article  CAS  Google Scholar 

  4. Karnoub, A.E. et al. Nature 449, 557–563 (2007).

    Article  CAS  Google Scholar 

  5. Rafii, S. & Lyden, D. Nat. Med. 9, 702–712 (2003).

    Article  CAS  Google Scholar 

  6. Kaplan, R.N. et al. Nature 438, 820–827 (2005).

    Article  CAS  Google Scholar 

  7. Bissell, M.J. & Radisky, D. Nat. Rev. Cancer 1, 46–54 (2001).

    Article  CAS  Google Scholar 

  8. Kitamura, T. et al. Nat. Genet. 39, 467–475 (2007).

    Article  CAS  Google Scholar 

  9. Welch, D.R., Schissel, D.J., Howrey, R.P. & Aeed, P.A. Proc. Natl. Acad. Sci. USA 86, 5859–5863 (1989).

    Article  CAS  Google Scholar 

  10. Gorelik, E., Wiltrout, R.H., Brunda, M.J., Holden, H.T. & Herberman, R.B. Int. J. Cancer 29, 575–581 (1982).

    Article  CAS  Google Scholar 

  11. Carmeliet, P. & Jain, R.K. Nature 407, 249–257 (2000).

    Article  CAS  Google Scholar 

  12. Eccles, S.A. & Welch, D.R. Lancet 369, 1742–1757 (2007).

    Article  CAS  Google Scholar 

  13. Christiano, A.P., Yoshida, B.A., Dubauskas, Z., Sokoloff, M. & Rinker-Schaeffer, C.W. Urol. Oncol. 5, 217–223 (2000).

    Article  CAS  Google Scholar 

  14. Weaver, V.M. & Gilbert, P. J. Cell Sci. 117, 1287–1290 (2004).

    Article  CAS  Google Scholar 

  15. Khakoo, A.Y. et al. J. Exp. Med. 203, 1235–1247 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Danny R. Welch is Leonard H. Robinson Professor and Douglas R. Hurst is an investigator in the Department of Pathology at the University of Alabama at Birmingham, 1670 University Blvd. VH-G019A, Birmingham, Alabama 35294-0019, USA. danwelch@uab.edu,

    Douglas R Hurst & Danny R Welch

Authors
  1. Douglas R Hurst
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Danny R Welch
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hurst, D., Welch, D. A MSC-ing link in metastasis?. Nat Med 13, 1289–1291 (2007). https://doi.org/10.1038/nm1107-1289

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1107-1289

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing