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Preventing kidney cell suicide

Nature Medicine volume 13, pages 1284–1285 (2007)Cite this article

Decreased levels of activated protein C allow for kidney cell death in a mouse model of diabetic nephropathy. The findings suggest that targeting the antiapoptotic protein C pathway could counteract kidney damage in individuals with diabetes (pages 1349–1358).

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Figure 1: Activated protein C (APC) modulates mitochondrial apoptosis in diabetic nephropathy.

Kim Caesar

References

  1. Brownlee, M. et al. in Williams Textbook of Endocrinology, 11th edn. (eds. Larsen, P.R., Kronenberg, H., Melmed, S. & Polonsky, K.) Ch. 32, 1417–1501 (W.B. Saunders, Philadelphia, in the press).

  2. Brownlee, M. Nature 414, 813–820 (2001).

    Article  CAS  Google Scholar 

  3. Du, X. et al. J. Clin. Invest. 112, 1049–1057 (2003).

    Article  CAS  Google Scholar 

  4. Isermann, B. et al. Nat. Med. 13, 1355–1364 (2007).

    Article  Google Scholar 

  5. Mosnier, L.O., Zlokovic, B.V. & Griffin, J.H. Blood 109, 3161–3172 (2007).

    Article  CAS  Google Scholar 

  6. Mosnier, L.O., Gale, A.J., Yegneswaran, S. & Griffin, J.H. Blood 104, 1740–1744 (2004).

    Article  CAS  Google Scholar 

  7. Riewald, M. & Ruf, W. J. Biol. Chem. 280, 19808–19814 (2005).

    Article  CAS  Google Scholar 

  8. Alano, C.C., Kauppinen, T.M., Vallis, A.V. & Swanson, R. Proc. Natl. Acad. Sci. USA 103, 9685–9690 (2006).

    Article  CAS  Google Scholar 

  9. Jordan, J. et al. Curr. Drug Deliv. 4, 225–231 (2007).

    Article  CAS  Google Scholar 

  10. Glaser, C.B. et al. J. Clin. Invest. 90, 2565–2573 (1992).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Michael Brownlee is Director of the Juvenile Diabetes Research Foundation International Center for Diabetic Complications Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, 10461, New York, USA

    Michael Brownlee

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  1. Michael Brownlee
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Brownlee, M. Preventing kidney cell suicide. Nat Med 13, 1284–1285 (2007). https://doi.org/10.1038/nm1107-1284

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