Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 13, 1284 - 1285 (2007)
doi:10.1038/nm1107-1284
Preventing kidney cell suicide
Michael Brownlee1
- Michael Brownlee is Director of the Juvenile Diabetes Research Foundation International Center for Diabetic Complications Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. e-mail: Brownlee@aecom.yu.edu
Abstract
Decreased levels of activated protein C allow for kidney cell death in a mouse model of diabetic nephropathy. The findings suggest that targeting the antiapoptotic protein C pathway could counteract kidney damage in individuals with diabetes (pages 1349–1358).
Diabetes is the leading cause of end-stage renal failure in most developed countries. Current therapy blocks the renin-angiotensin system, but this approach only delays dialysis or kidney transplantation1.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosisNature Medicine Article (01 Nov 2007)
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood?brain barrierJournal of Cerebral Blood Flow & Metabolism Regional Development
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood?brain barrierJournal of Cerebral Blood Flow & Metabolism Regional Development
The thrombomodulin?protein C system is essential for the maintenance of pregnancyNature Medicine Article (01 Mar 2003)
