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Nature Medicine 13, 1281 - 1282 (2007)
doi:10.1038/nm1107-1281

A deer in the headlights: BAMBI meets liver fibrosis

Scott L Friedman1

  1. Scott L. Friedman is in the Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, Box 1123, 1425 Madison Ave., Room 1170C, New York, New York 10029-6574, USA. e-mail: scott.friedman@mssm.edu

Lipopolysaccharide signaling through the Toll-like receptors downregulates an inhibitory pseudoreceptor of TGF-beta, enhancing hepatic fibrosis and liver injury (pages 1324–1332).

Chronic liver disease leads to continual injury and a wound-healing response in the organ, which causes a torrent of problems. The injuries contribute to a cascade of events in which gut bacteria leak from the intestine, provoking the recruitment of inflammatory cells, which drown the microenvironment in fibrogenic cytokines.

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