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From the following article

Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1

Heiko Johnen, Shu Lin, Tamara Kuffner, David A Brown, Vicky Wang-Wei Tsai, Asne R Bauskin, Liyun Wu, Greg Pankhurst, Lele Jiang, Simon Junankar, Mark Hunter, W Douglas Fairlie, Nicola J Lee, Ronaldo F Enriquez, Paul A Baldock, Eva Corey, Fred S Apple, MaryAnn M Murakami, En-Ju Lin, Chuansong Wang, Matthew J During, Amanda Sainsbury, Herbert Herzog & Samuel N Breit

Nature Medicine 13, 1333 - 1340 (2007) Published online: 4 November 2007

doi:10.1038/nm1677

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Figure 1

Effect of MIC-1 on mouse weight, food intake and body composition.

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Figure 2

Effect of MIC-1 on body weight in mice and in humans with advanced prostate cancer.

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Figure 3

Effect of prolonged action of MIC-1.

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Figure 4

MIC-1 receptor identification.

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Figure 5

MIC-1 induces alteration in expression of neuropeptide Y and POMC in neurons expressing phosphorylated Stat3.

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Figure 6

MIC-1, injected systemically or locally, induces Stat3 phosphorylation in the hypothalamus, even in db/db mice.

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