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Volume 13 Issue 11, November 2007

On page 1375, William Harnett and his colleagues report that ES-62, a protein of filarial nematodes, inhibits the release of allergy mediators from human mast cells. This observation helps explain why the prevalence of allergy has steeply increased in developed countries, but not in regions in which infection by parasitic worms is common. The cover shows a micrograph of a human mast cell. Credit: CNRI/Photo Researchers, Inc

Volume 13 Issue 11

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Editorial

  • It can take twice as long to get a PhD in biomedical sciences in the US as it does in other countries such as the UK and Australia. Are US PhDs worth more, or are there advantages to a speedier system?

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News

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News Feature

  • What makes some people more prone to depression and less likely to respond to the medicines that can treat it? Comparing the genetic makeup of thousands of people is uncovering some answers, reports Cassandra Willyard.

    • Cassandra Willyard
    News Feature
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Q&A

  • In 2000, former Genentech executive Victoria Hale and her husband launched the Institute for OneWorld Health from the first floor of their San Francisco home. They called the institute “the world's first nonprofit pharmaceutical company” and intended it to address diseases of poverty, which are generally neglected by drug companies. For its first project, the group tried to revive paromomycin, a 60-year-old antibiotic, to treat a disease called visceral leishmaniasis. In September 2006, India approved the drug. OneWorld Health has in the meantime grown to 50 employees and a $90 million budget. On 27 September, Hale stepped down from her role as chief executive officer of the institute. Here she tells Erika Check Hayden what's next for her and for the unique organization she launched.

    • Erika Check Hayden
    Q&A
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Correspondence

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Book Review

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News & Views

  • Histone deacetylase inhibitors, which are in clinical use as anticancer agents, also affect the biology of regulatory T cells. These inhibitors may also hold promise as immunomodulatory drugs (pages 1299–1307).

    • Pavan Reddy
    • Weiping Zou
    News & Views

  • Decreased levels of activated protein C allow for kidney cell death in a mouse model of diabetic nephropathy. The findings suggest that targeting the antiapoptotic protein C pathway could counteract kidney damage in individuals with diabetes (pages 1349–1358).

    • Michael Brownlee
    News & Views

  • Two studies suggest how mutations in the APC tumor suppressor gene can contribute to chromosomal aberrations in precancerous cells.

    • Craig J Ceol
    • David Pellman
    • Leonard I Zon
    News & Views

  • A protein produced by parasitic roundworms that inhibits the inflammatory response is shown to prevent mast cell activation. The protein could potentially be used for the management of allergies and asthma (pages 1375–1381).

    • Edward J Pearce
    News & Views

  • Mesenchymal stem cells promote the dissemination of neoplastic cells in a mouse model of breast cancer. The findings sound a cautionary note for anticancer therapies that rely on these cells and provoke a re-evaluation of how metastases form.

    • Douglas R Hurst
    • Danny R Welch
    News & Views
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Brief Communication

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Letter

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