Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 13, 1146 - 1147 (2007)
doi:10.1038/nm1007-1146b
'Multipurpose oxidase' in atherogenesis
Daniel J Rader1 & Harry Ischiropoulos2
- Daniel J. Rader is in the Institute for Translational Medicine and Therapeutics, the Cardiovascular Institute and the Institute for Diabetes Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. e-mail: rader@mail.med.upenn.edu
- Harry Ischiropoulos is in the Stokes Research Institute and the Departments of Pediatrics and Pharmacology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. e-mail: ischirop@mail.med.upenn.edu
Abstract
A new mechanism of protein carbamylation links inflammation, cardiovascular disease and smoking (pages 1176–1184).
Despite being much-studied and a worldwide scourge, the pathogenesis of atherosclerotic cardiovascular disease remains incompletely understood. Although inflammation and oxidative stress are generally believed to have important roles in this disease1, the molecular mechanisms by which they promote the formation of plaques within the cardiovascular wall (atherosclerosis) are still unclear.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Protein carbamylation links inflammation, smoking, uremia and atherogenesisNature Medicine Article (01 Oct 2007)
