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From the following article

27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen

Michihisa Umetani, Hideharu Domoto, Andrew K Gormley, Ivan S Yuhanna, Carolyn L Cummins, Norman B Javitt, Kenneth S Korach, Philip W Shaul & David J Mangelsdorf

Nature Medicine 13, 1185 - 1192 (2007) Published online: 16 September 2007

doi:10.1038/nm1641

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

27HC inhibition of estrogen receptors.

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Figure 2

27HC inhibits the actions of E2 on NO production in vascular cells.

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Figure 3

27HC decreases vascular NOS expression in an ER-dependent manner.

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Figure 4

27HC Inhibits nontranscriptional effects of E2 on NOS enzyme activity in vascular cells.

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Figure 5

27HC inhibits E2-induced endothelial cell migration and reendothelialization in mice.

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Figure 6

Model of 27HC inhibition of the vasoprotective effects of estrogen.

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