Brief Communication abstract
Nature Medicine 13, 1173 - 1175 (2007)
Published online: 9 September 2007 | doi:10.1038/nm1651
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
Hania Kebir1, Katharina Kreymborg2, Igal Ifergan1, Aurore Dodelet-Devillers1, Romain Cayrol1, Monique Bernard1, Fabrizio Giuliani3, Nathalie Arbour1, Burkhard Becher2 & Alexandre Prat1
TH17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, TH17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.
- Neuroimmunology Unit, Center for the Study of Brain Diseases, Centre Hospitalier de l'Université de Montréal–Notre-Dame Hospital, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada.
- Neurology Department, Division of Neuroimmunology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
- Department of Medicine, Division of Neurology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.
Correspondence to: Alexandre Prat1 e-mail: a.prat@umontreal.ca
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