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Nature Medicine 13, 1137 - 1138 (2007)
doi:10.1038/nm1007-1137
It's what you do with the fat that matters!
Clinton R Bruce1 & Mark A Febbraio1
- Clinton R. Bruce and Mark A. Febbraio are in the Cellular and Molecular Metabolism Laboratory, Diabetes and Metabolism Division, Baker Heart Research Institute, Melbourne, Victoria 3004, Australia. e-mail: mark.febbraio@baker.edu.au
Abstract
Obesity and a diet rich in saturated fatty acids can lead to high lipid levels in the liver and insulin resistance. However, inhibition of a key enzyme that elongates long-chain saturated fatty acids can protect against insulin resistance in fatty livers, even with concurrent obesity (pages 1193–1202).
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