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Nature Medicine 13, 26–28 (1 January 2007) | doi:10.1038/nm0107-26

IL-23: a master regulator in Crohn disease

Markus F Neurath

An innovative genetic study in people and two other recent studies in mice uncover a key factor in the pathogenesis of inflammatory bowel disease (IBD). The research puts the spotlight on the pro-inflammatory cytokine interleukin (IL)-23 (refs.