1. The author is in the Departments of Pediatrics and Genetics, Stanford University, Stanford, California 94305, USA. e-mail: julsage@stanford.edu

Abstract

The retinoblastoma gene (RB) was the first tumor suppressor gene cloned. But, until recently, little clinical progress had been made to target human tumors deficient in RB function. A new approach emerges from studying retinoblastoma tumors.

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