Nature Medicine
- 12, 1048 - 1055 (2006)
Published online: 13 August 2006; | doi:10.1038/nm1471
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolismLiming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz Supplementary Fig. 1 (pdf 292K) Induction of NR4A expression by the cAMP axis requires CREB family proteins but not PGC-1 . Supplementary Fig. 2 (pdf 248K) Regulation of gene expression by Nur77 does not require PGC-1 . Supplementary Fig. 3 (pdf 304K) Sequences and locations of putative NBREs in promoters of gluconeogenic genes. Supplementary Fig. 4 (pdf 176K) Effects of Nur77 expression on key genes involved in control of glucose metabolism. Supplementary Fig. 5 (pdf 216K) A mutant Nur77 receptor antagonizes NR4A action on target promoters. Supplementary Table 1 (pdf 16K) Real-time PCR (SyberGreen) primers used.
|