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Article
Nature Medicine - 12, 1048 - 1055 (2006)
Published online: 13 August 2006; | doi:10.1038/nm1471

NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz

Supplementary Fig. 1 (pdf 292K)
Induction of NR4A expression by the cAMP axis requires CREB family proteins but not PGC-1alpha.

Supplementary Fig. 2 (pdf 248K)
Regulation of gene expression by Nur77 does not require PGC-1alpha.

Supplementary Fig. 3 (pdf 304K)
Sequences and locations of putative NBREs in promoters of gluconeogenic genes.

Supplementary Fig. 4 (pdf 176K)
Effects of Nur77 expression on key genes involved in control of glucose metabolism.

Supplementary Fig. 5 (pdf 216K)
A mutant Nur77 receptor antagonizes NR4A action on target promoters.

Supplementary Table 1 (pdf 16K)
Real-time PCR (SyberGreen) primers used.


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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