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Letter
Nature Medicine 12, 1075–1080 (1 September 2006) | doi:10.1038/nm1459
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
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Abstract
Vascular smooth muscle cell (VSMC) apoptosis occurs in many arterial diseases, including aneurysm formation, angioplasty restenosis and atherosclerosis. Although VSMC apoptosis promotes vessel remodeling, coagulation and inflammation, its precise contribution to these diseases is unknown, given that apoptosis frequently accompanies vessel injury or alterations to flow.
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