Regulatory T cells are known for their ability to tame the immune response. A molecule has now been identified that can sensitize T cells to this suppressive activity. The findings open the door to new ways of modulating immunity (pages 1088–1092).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sakaguchi, S. Annu. Rev. Immunol. 22, 531–562 (2004).
King, C.G. et al. Nat. Med. 12, 1088–1092 (2006).
Akira, S., Uematsu, S. & Takeuchi, O. Cell 124, 783–801 (2006).
Sun, L., Deng, L., Ea, C.K., Xia, Z.P. & Chen, Z.J. Mol. Cell 14, 289–301 (2004).
Wu, H. & Arron, J.R. Bioessays 25, 1096–1105 (2003).
Deane, J.A. & Fruman, D.A. Annu. Rev. Immunol. 22, 563–598 (2004).
Di Cristofano, A. et al. Science 285, 2122–2125 (1999).
Borlado, L.R. et al. FASEB J. 14, 895–903 (2000).
Parsons, M.J. et al. J. Immunol. 167, 42–48 (2001).
Suzuki, A. et al. Immunity 14, 523–534 (2001).
Rathmell, J.C., Elstrom, R.L., Cinalli, R.M. & Thompson, C.B. Eur. J. Immunol. 33, 2223–2232 (2003).
Ohashi, P.S. Nat. Rev. Immunol. 2, 427–438 (2002).
Wong, B.R. et al. Mol. Cell 4, 1041–1049 (1999).
Wong, F., Hull, C. Blood 103, 4520–4526 (2004).
Wohlfert, E.A., Gorelik, L., Mittler, R., Flavell, R.A. & Clark, R.B. J. Immunol. 176, 1316–1320 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohashi, P., Yeh, W. Supressing the supressors. Nat Med 12, 1000–1002 (2006). https://doi.org/10.1038/nm0906-1000
Issue Date:
DOI: https://doi.org/10.1038/nm0906-1000
