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Nature Medicine - 12, 1048 - 1055 (2006)
Published online: 13 August 2006; | doi:10.1038/nm1471

NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism

Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz

 
Figure 1 thumbnailFigure 1.
Induction of NR4A receptor expression in liver in response to the glucagon-cAMP axis and fasting.

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Complementary regulation of glucose metabolism by Nur77 and PGC-1alpha in primary hepatocytes.

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Figure 3 thumbnailFigure 3.
NR4A proteins are direct regulators of genes involved in glucose metabolism.

Full FigureFull Figure and legend (59K)		 Figure 4 thumbnailFigure 4.
Activation of gluconeogenesis by Nur77 in vivo.

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Figure 5 thumbnailFigure 5.
Inhibition of NR4A receptor activity lowers blood glucose in physiology and diabetes.

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