A mechanism that may underlie a form of human kidney failure has been delineated in knockout mice. Activation of the oxygen-regulated transcription factor Hif1 and its target gene Cxcr4 leads to increased cell proliferation that interferes with the function of the glomerulus (pages 1071–1077).
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Kim Caesar
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Semenza, G. Hypoxia pathway linked to kidney failure. Nat Med 12, 996–997 (2006). https://doi.org/10.1038/nm0906-996
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DOI: https://doi.org/10.1038/nm0906-996
