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Article
Nature Medicine - 12, 925 - 932 (2006)
Published online: 30 July 2006; | doi:10.1038/nm1448

Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness

Jolanta M Topczewska, Lynne-Marie Postovit, Naira V Margaryan, Anthony Sam, Angela R Hess, William W Wheaton, Brian J Nickoloff, Jacek Topczewski & Mary J C Hendrix

Supplementary Fig. 1 (pdf 532K)
Schematic representation of melanoma cell transplantation experiments.

Supplementary Fig. 2 (pdf 2M)
The overexpression of the lefty1 inhibits secondary axis formation induced by transplanted aggressive C8161 melanoma cells.

Supplementary Fig. 3 (pdf 436K)
Patterns of Nodal expression in primary and metastatic cutaneous melanoma and breast carcinoma cell lines.

Supplementary Fig. 4 (pdf 892K)
Nodal-mediated signaling and gene regulation in melanoma cells.

Supplementary Fig. 5 (pdf 688K)
TUNEL assay of melanoma cells treated with MONodal or SB431542.

Supplementary Note (pdf 92K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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