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Nature Medicine 12, 887 - 888 (2006)
doi:10.1038/nm0806-887
Stopping cancer before it colonizes
Carrie W Rinker-Schaeffer1 & Jonathan A Hickson1
- Carrie W. Rinker-Schaeffer is in the Departments of Surgery, Medicine and Obstetrics and Gynecology, and Jonathan A. Hickson is in the Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois 60637, USA. e-mail: crinkers@midway.uchicago.edu
Abstract
Controlling the growth of cancer cells at metastatic sites is one goal of cancer drug development. Studies of metastasis suppressor function bring this long-sought goal closer (pages 933–938).
Primary tumor formation and metastasis are distinct processes. For instance, cancer cells can express metastasis suppressors that block cell proliferation at secondary or metastatic sites yet permit cell proliferation at primary sites1.
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