Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature Medicine 12, 887 - 888 (2006)
doi:10.1038/nm0806-887
Stopping cancer before it colonizes
Carrie W Rinker-Schaeffer1 & Jonathan A Hickson1
- Carrie W. Rinker-Schaeffer is in the Departments of Surgery, Medicine and Obstetrics and Gynecology, and Jonathan A. Hickson is in the Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois 60637, USA. e-mail: crinkers@midway.uchicago.edu
Abstract
Controlling the growth of cancer cells at metastatic sites is one goal of cancer drug development. Studies of metastasis suppressor function bring this long-sought goal closer (pages 933–938).
Primary tumor formation and metastasis are distinct processes. For instance, cancer cells can express metastasis suppressors that block cell proliferation at secondary or metastatic sites yet permit cell proliferation at primary sites1.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppressionNature Medicine Letter (01 Aug 2006)
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradationNature Medicine Letter (01 Dec 2007)
Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathologyMolecular Systems Biology Article (16 Jun 2009)
See all 4 matches for Research