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Nature Medicine 12, 882 - 884 (2006)
doi:10.1038/nm0806-882
Embryogenesis meets tumorigenesis
John T Lee1 & Meenhard Herlyn1
- The authors are in the Program of Molecular & Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA. e-mail: herlynm@wistar.org
Abstract
Transplantation of metastatic melanoma cells into zebrafish embryo disrupts development—and identifies a potential new drug target for this deadly cancer (pages 925–932).
Metastatic melanoma remains one of the deadliest diseases, with a 5-year survival rate of less than 20%. The identification of new biological mediators of disease is the most rational approach to developing drugs to shift these dismal odds.
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