Nature Medicine
- 12, 895 - 904 (2006)
Published online: 4 August 2006; | doi:10.1038/nm1469
Tumor metastasis: mechanistic insights and clinical challengesPatricia S Steeg
Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute Building 37, Room 1122, National Institutes of Health, Bethesda, Maryland 20892, USA steegp@mail.nih.gov
Metastatic disease is the primary cause of death for most cancer patients. Complex and redundant pathways involving the tumor cell and the microenvironment mediate tumor invasion at the primary site, survival and arrest in the bloodstream, and progressive outgrowth at a distant site. Understanding these pathways and their dynamic interactions will help identify promising molecular targets for cancer therapy and key obstacles to their clinical development.
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