Nature Medicine 12, 809 - 816 (2006)
Published online: 2 July 2006; | doi:10.1038/nm1440
E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasisCho-Rok Jung, Kyung-Sun Hwang, Jinsang Yoo, Won-Kyung Cho, Jin-Man Kim, Woo Ho Kim
& Dong-Soo Im Supplementary Fig. 1 (pdf 100K)
F-UCP expressed in UCP-negative cells co-sediments with pVHL. Supplementary Fig. 2 (pdf 92K)
UCP targets pVHL in cells under hypoxic conditions, thereby accumulating active HIF-1 . Supplementary Fig. 3 (pdf 92K)
Recombinant GST-UCP, but not GST-UCPm is catalytically active. Supplementary Fig. 4 (pdf 120K)
UCP ubiquitinates pVHL in vitro
Supplementary Fig. 5 (pdf 128K)
UCP specifically targets pVHL for degradation. Supplementary Fig. 6 (pdf 88K)
UCP targets pVHL for degradation in Ck-K1 cells, thereby stabilizing HIF-1. Supplementary Fig. 7 (pdf 116K)
The specificity for UCP-siRNA. Supplementary Fig. 8 (pdf 112K)
Detection of Ad.F-UCP genome and F-UCP transcript in tumors excised from mice.
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