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Letter
Nature Medicine 12, 824 - 828 (2006)
Published online: 11 June 2006; | doi:10.1038/nm1418

Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia

Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop & Steven E Arnold

Supplementary Fig. 1 (pdf 52K)
NRG1 or NMDA stimulation activates intracellular signal transduction in postmortem brains.

Supplementary Fig. 2 (pdf 68K)
NRG1 stimulation induces erbB4 activation in mouse brains at varied postmortem intervals.

Supplementary Fig. 3 (pdf 68K)
Haloperidol treatment does not enhance NRG1 induced erbB4 activation.

Supplementary Fig. 4 (pdf 56K)
Association of erbB4 with NMDAR is enhanced in PFCs of SCZ subjects.

Supplementary Fig. 5 (pdf 52K)
Association of PSD-95 with NMDAR is enhanced in the PFC of SCZ subjects.

Supplementary Fig. 6 (pdf 160K)
ErbB4 expression in human postmortem brains.

Supplementary Table 1 (pdf 72K)
Demographic information on the subjects of postmortem brains.

Supplementary Note (pdf 156K)


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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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