Figures and Tables - Nature Medicine

Figures and Tables

Nature Medicine 12, 852 - 855 (2006)
Published online: 25 June 2006; | doi:10.1038/nm1437

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

Roman K Thomas, Elizabeth Nickerson, Jan F Simons, Pasi A Jänne, Torstein Tengs, Yuki Yuza, Levi A Garraway, Thomas LaFramboise, Jeffrey C Lee, Kinjal Shah, Keith O'Neill, Hidefumi Sasaki, Neal Lindeman, Kwok-Kin Wong, Ana M Borras, Edward J Gutmann, Konstantin H Dragnev, Ralph DeBiasi, Tzu-Hsiu Chen, Karen A Glatt, Heidi Greulich, Brian Desany, Christine K Lubeski, William Brockman, Pablo Alvarez, Stephen K Hutchison, J H Leamon, Michael T Ronan, Gregory S Turenchalk, Michael Egholm, William R Sellers, Jonathan M Rothberg & Matthew Meyerson

Figure 1.
Failure of Sanger sequencing to detect clinically relevant EGFR mutations in a malignant pleural effusion specimen with low tumor content.

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Figure 2.
Detection of clinically relevant EGFR kinase domain mutations by array-based pyrosequencing in a malignant pleural effusion specimen with low tumor content.

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