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Teasing out the tangles

Tau aggregates into insoluble tangles in the brains of individuals with Alzheimer disease. Recent work suggests that these tangles do not cause the cognitive decline that typifies the disease.

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Figure 1: Axonal transport proceeds along microtubule tracks (blue), covered by microtubule-associated proteins (MAPs) such as tau (tan), which are involved in correct spacing and stabilization of the tracks (lower panel).

Katie Ris

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Kins, S., Beyreuther, K. Teasing out the tangles. Nat Med 12, 764–765 (2006). https://doi.org/10.1038/nm0706-764

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