Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Pinpointing plaques with PIB

The promise of disease-modifying treatments for Alzheimer disease calls for biomarkers that enable early diagnosis. A new discovery shows how to visualize amyloid pathology in living Alzheimer patients.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: PET images produced using Pittsburgh Compound-B (PIB) shown in sagittal (top) and transaxial (bottom) views.

References

  1. Masters, C.L. et al. Proc. Natl. Acad. Sci. USA 82, 4245–4249 (1985).

    Article  CAS  Google Scholar 

  2. Hardy, J. & Selkoe, D.J. Science 297, 353–356 (2002).

    Article  CAS  Google Scholar 

  3. Blennow, K., de Leon, M.J. & Zetterberg, H. Lancet (In the press).

  4. Klunk, W.E. et al. Ann. Neurol. 55, 306–319 (2004).

    Article  CAS  Google Scholar 

  5. Klunk, W.E. et al. J. Neurosci. 23, 2086–2092 (2003).

    Article  CAS  Google Scholar 

  6. Klunk, W.E., et al. J. Neurosci. 25, 10598–10606 (2005).

    Article  CAS  Google Scholar 

  7. Fagan, A.M. et al. Ann. Neurol. 59, 512–519 (2006).

    Article  CAS  Google Scholar 

  8. Petersen, R.C. J. Intern. Med. 256, 183–194 (2004).

    Article  CAS  Google Scholar 

  9. Duff, K. & Suleman, F. Brief. Funct. Genomic. Proteomic. 3, 47–59 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blennow, K., Zetterberg, H. Pinpointing plaques with PIB. Nat Med 12, 753–754 (2006). https://doi.org/10.1038/nm0706-753

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0706-753

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing