Nature Medicine
- 12, 732 - 734 (2006)
doi:10.1038/nm0706-732
VEGF inhibitors make bloodChristian Fischer, Peter Carmeliet & Edward M Conway
The authors are at the Center for Transgene Technology and Gene Therapy, KU Leuven, Flanders Interuniversity Institute for Biotechnology (VIB), Leuven, Belgium. peter.carmeliet@med.kuleuven.be
kanjiFindings in mice suggest that treatment with VEGF inhibitors prompts the upregulation of erythropoietin (Epo), a powerful cytokine and regulator of blood cell development. Could Epo be dulling the therapeutic effects of VEGF inhibition?
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