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Nature Medicine 12, 657 - 664 (2006)
Published online: 21 May 2006; | doi:10.1038/nm1417

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

Orit Kollet, Ayelet Dar, Shoham Shivtiel, Alexander Kalinkovich, Kfir Lapid, Yejezkel Sztainberg, Melania Tesio, Robert M Samstein, Polina Goichberg, Asaf Spiegel, Ari Elson & Tsvee Lapidot

 
Figure 1 thumbnailFigure 1.
Bleeding and LPS trigger mobilization of progenitors and formation of OCLs.

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 Figure 2 thumbnailFigure 2.
SDF-1 and HGF induce formation of TRAP+ OCLs and mobilization of progenitors.

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Figure 3 thumbnailFigure 3.
RANKL-mediated mobilization of progenitors.

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 Figure 4 thumbnailFigure 4.
Mechanisms of mobilization induced by bone-resorbing OCLs.

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Figure 5 thumbnailFigure 5.
CTK cleaves SDF-1.

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 Figure 6 thumbnailFigure 6.
A proposed model for the role of bone-resorbing OCLs in stress-induced stem cell mobilization.

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