Nature Medicine
- 12, 610 - 611 (2006)
doi:10.1038/nm0606-610
Osteoclasts eat stem cells out of house and home
Louise E Purton & David T Scadden
Louise E. Purton and David T. Scadden are at the Center for Regenerative Medicine, Massachusetts General Hospital, and Harvard Stem Cell Institute, Boston, Massachusetts 02114, USA. scadden.david@mgh.harvard.edu
kanjiOsteoclasts carve out the marrow space where hematopoietic stem cells reside, but they have been considered bystanders during hematopoiesis. Osteoclasts are now shown to mediate stem cell mobilization, enabling stem cell emigration from the marrow to the circulation (pages 657 – 664).
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