The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

Marie-Julie Dubois, Sébastien Bergeron, Hyo-Jeong Kim, Luce Dombrowski, Mylène Perreault, Bénédicte Fournès, Robert Faure, Martin Olivier, Nicole Beauchemin, Gerald I Shulman, Katherine A Siminovitch, Jason K Kim & André Marette

Supplementary Fig. 1 (pdf 92K)
SHP-1 immunoreactivity in liver and skeletal muscle of wild-type and Ptpn6 ^me/me mice.

Supplementary Fig. 2 (pdf 52K)
Effect of wortmannin on 2-DG uptake by soleus and EDL muscles of wild-type and SHP-1–deficient Ptpn6 ^me-v/me-v mice.

Supplementary Fig. 3 (pdf 108K)
Insulin signaling in muscle and liver of wild-type and Ptpn6 ^me-v/me-v or lacZ- and DNSHP-1–transduced mice.

Supplementary Fig. 4 (pdf 80K)
PTEN tyrosine phosphorylation in liver of animal models of SHP-1 deficiency.

Supplementary Fig. 5 (pdf 356K)
In vivo transduction of liver after systemic delivery of adenovirally encoded GFP.

Supplementary Table 1 (pdf 24K)
Physiological parameters of wild-type and SHP-1–deficient mice.

Supplementary Table 2 (pdf 20K)
Quantification of changes in insulin-stimulated tyrosine phosphorylation of insulin signaling problems in tissues of Ptpn6 ^me-v/me-v and DNSHP-1–transduced mice.

Supplementary Methods (pdf 28K)

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