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Volume 12 Issue 5, May 2006

Signaling through receptor tyrosine kinases (RTKs) can stimulate cell proliferation, and its aberrant activation is implicated in many cancers. Mig6 is an adapter protein that mitigates the response of RTKs to cellular growth factors. On page 568, Ferby et al. show that mice lacking Mig6 have a hyperactivated response to mitogens and develop tumors at high frequency, highlighting the delicate balance between promotion and suppression of RTK signaling. The cover depicts cell proliferation in cancerous gastrointestinal crypts in a Mig6-deficient mouse.

Volume 12 Issue 5

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Editorial

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News

  • Rising demand has created a thriving market for human body parts—and not all of it above ground. Emily Waltz explores the unsavory world of tissue trade.

    • Emily Waltz
    News

  • Even in a constant state of jetlag, Yoshihiro Kawaoka is a fiercely productive flu researcher. Wonder what he could accomplish with a little bit of sleep?

    • Apoorva Mandavilli
    News

  • What makes a scientist deceive? Faked data, fudged numbers, filched ideas: how common in science are these grave sins? There may only be a handful of cases where scientists managed to fool the whole world—a Jon Hendrik Schön here, a Woo-Suk Hwang there—but survey after survey reveals that your garden-variety fraud is more prevalent than anyone cares to admit. Whose responsibility is it to police misconduct in science? And what motivates it in the first place? In the following pages, we take a look at what prompts those ethical missteps and what governments, universities, journals—and you—can do about it.

    • David Cyranoski
    News

  • Governments, universities and journals all have roles to play in dealing with fraud, says Emma Marris.

    • Emma Marris
    News

  • Examples of fraud—real or alleged—are startlingly common, but a few cases become the stuff of folklore. What happens after the dust settles?

    • Paroma Basu
    News

  • Peer review, whether of grants or publications, is a matter of trust. And sometimes, scientists break that trust.

    • Tinker Ready
    News
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Correspondence

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Book Review

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News & Views

  • Multiple sclerosis occurs when T cells attack myelin in the central nervous system. Experiments in a mouse model of the disease suggest that neurons fight back by inducing regulatory T cells that dampen the immune response (pages 518–525).

    • Robert S Fujinami
    News & Views

  • The versatile neurotransmitter GABA acquires a new role in the control of appetite by the hypothalamus. In this region of the brain, a regulator of GABAA receptor expression seems to respond to energy levels (pages 526–533).

    • Brenda Smith Richards
    • Hans-Rudi Berthoud
    News & Views

  • In vitro experiments have suggested that the TRPA1 ion channel senses various noxious stimuli. Many of these findings are now borne out in mice, in line with the notion that TRPA1 inhbitors might be useful in treating pain.

    • Ardem Patapoutian
    • Lindsey Macpherson
    News & Views

  • A new approach to killing tumors combines two methods that each alone have shortcomings. A tumor-killing virus is loaded into a cell type that homes to tumors, thereby evading the antiviral immune response.

    • Kevin Harrington
    • Richard Vile
    News & Views

  • A new approach to personalized drug treatment emerges in a study examining the metabolic profile of rats. The profile, which is a measurement of small molecules such as sugars and amino acids, is used to predict the response to drugs that are toxic to the liver. This study proposes the extension of this concept into humans as a way of predicting the outcome of a therapy for a given profile.

    • John N Haselden
    • Andrew W Nicholls
    News & Views

  • Ciliary neurotrophic factor (CNTF) enhances fatty-acid oxidation in muscle and reduces insulin resistance in obese, diabetic mice. Because skeletal muscle is the major site of insulin-mediated glucose uptake, this action of CNTF could benefit individuals with diabetes (pages 541–548).

    • Rexford S Ahima
    News & Views
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