Ciliary neurotrophic factor (CNTF) enhances fatty-acid oxidation in muscle and reduces insulin resistance in obese, diabetic mice. Because skeletal muscle is the major site of insulin-mediated glucose uptake, this action of CNTF could benefit individuals with diabetes (pages 541–548).
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References
Petersen, K.F. & Shulman, G.I. Am. J. Med. 119 Suppl 1, S10–S16 (2006)
Unger, R.H. Trends Endocrinol. Metab. 14, 398–403 (2003)
Flier, J.S. Cell 116, 337–350 (2004).
Watt, M.J. et al. Nat. Med. 12, 541–548 (2006).
Watt, M.J. et al. Endocrinology 147, 2077–2085 (2006).
Gloaguen, I. et al. Proc. Natl. Acad. Sci. USA 94, 6456–6461 (1997).
Lambert, P.D. et al. Proc. Natl. Acad. Sci. USA 98, 4652–4657 (2001).
Kokoeva, M.V., Yin, H. & Flier, J.S. Science 310, 679–683 (2005).
Kahn, B.B. et al. Cell Metab. 1, 15–25 (2005).
Tartaglia, L.A. J. Biol. Chem. 272, 6093–6096 (1997).
Ettinger, M.P. et al. JAMA 289, 1826–1832 (2003).
Kelly, J.F. et al. Diabetes 53, 911–920 (2004).
Watt, J.A. et al. Exp. Neurol. 197, 206–214 (2006).
Sleeman, M.W. et al. Proc. Natl. Acad. Sci. USA 100, 14297–14302 (2003).
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Ahima, R. Overcoming insulin resistance with CNTF. Nat Med 12, 511–512 (2006). https://doi.org/10.1038/nm0506-511
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DOI: https://doi.org/10.1038/nm0506-511
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