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Overcoming insulin resistance with CNTF

Ciliary neurotrophic factor (CNTF) enhances fatty-acid oxidation in muscle and reduces insulin resistance in obese, diabetic mice. Because skeletal muscle is the major site of insulin-mediated glucose uptake, this action of CNTF could benefit individuals with diabetes (pages 541–548).

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Figure 1: CNTF counteracts fatty-acid flux and lipid accumulation in liver and muscle.

Katie Ris

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Ahima, R. Overcoming insulin resistance with CNTF. Nat Med 12, 511–512 (2006). https://doi.org/10.1038/nm0506-511

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