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Nature Medicine 12, 484 (2006)
Published online: 27 April 2006 | doi:10.1038/nm0506-484a
Sheep study calls for closer look at prion hypothesis
Michael Hopkin1
- London
Abstract
Prions may not cause mad cow disease or scrapie, controversial report claims.
The infectious agent behind diseases such as mad cow, scrapie and variant Creutzfeld-Jakob disease may not necessarily be rogue prion proteins, say British researchers—a suggestion that flies in the face of current dogma about how these diseases are spread.Although deformed prions are a characteristic of these diseases, they may not be the initial infectious agent, says lead researcher Martin Jeffrey of the Veterinary Laboratories Agency–Lasswade near Edinburgh.
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